Buffering excess hydrogen ions increases ischemic tolerance in hypertrophied myocardium
نویسندگان
چکیده
منابع مشابه
AT1-receptor blockade enhances ischemic preconditioning in hypertrophied rat myocardium.
The purpose of this study was to determine whether ischemic preconditioning protects contractile function in hypertrophied rat myocardium from ischemia-reperfusion (I/R) injury. Male salt-sensitive rats were fed a high-salt diet for 2 wk to induce myocardial hypertrophy. Nonhypertrophied hearts were obtained from age-matched Sprague-Dawley (SD) rats fed a regular diet. Heart weight-to-body weig...
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CARDIAC REMODELING has been described as both an adaptive and a maladaptive process. The adaptive component enables the heart to maintain function in response to pressure overload and has the effect of decreasing ventricular wall stress and compensates for the increased workload preserving cardiac function. Along with the changes in ventricular mechanics, the development of hypertrophy is accom...
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BACKGROUND Gap junctions are a determinant of myocardial conduction. Disturbances of gap-junctional content may account for abnormalities of impulse propagation, contributing to the arrhythmic tendency and mechanical inefficiency of ischemic and hypertrophied myocardium. The aim of this study was to characterize gap junction organization in normal human ventricular myocardium and to establish w...
متن کاملSTAT-3 activation is necessary for ischemic preconditioning in hypertrophied myocardium.
The JAK-STAT pathway is activated in the early and late phases of ischemic preconditioning (IPC) in normal myocardium. The role of this pathway and the efficacy of IPC in hypertrophied hearts remain largely unknown. We hypothesized that phosphorylated STAT-3 (pSTAT-3) is necessary for effective IPC in pressure-overload hypertrophy. Male Sprague-Dawley rats 8 wk after thoracic aortic constrictio...
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It has long been recognized that a brief episode of myocardial ischemia causes reversible myocyte injury, "reversible" being defined by the fact that early restoration of arterial flow prevents infarction and permits eventual restoration of normal myocardial structure, function, and metabolism. However, numerous studies during the last 15 years1-5 have revealed that complete recovery is not imm...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2019
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2018.10.033